A cyclooxygenase and lipoxygenase inhibitor
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8,11,14-Eicosatriynoic Acid

Item No. 10007900

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8,11,14-eicosatriynoic acid
CAS Number
34262-64-1
Synonyms
  • 8,11,14-ETI
  • FA 20:6
Molecular Formula
C20H28O2
Formula Weight
300.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.15 M Tris-HCl (pH 8.5): 1 mg/mlDMF: 100 mg/mlDMSO: 100 mg/mlEthanol: 100 mg/mlPBS (pH 7.2): 0.15 mg/ml
SMILES
CCCCCC#CCC#CCC#CCCCCCCC(O)=O
InChi Code
InChI=1S/C20H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-5,8,11,14-19H2,1H3,(H,21,22)
InChi Key
QLLIWTBTVOPGCM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $134

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    5 mg

    $466

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    Product Description

    8,11,14-Eicosatriynoic acid is an inhibitor of prostaglandin and leukotriene biosynthesis as well as arachidonic acid induced platelet aggregation.1 It inhibits cyclooxygenase (IC50 = 14 µM), human 12-lipoxygenase (IC50 = 0.46 µM), 5-lipoxygenase (IC50 = 25 µM) and the actions of slow-reacting substance of anaphylaxis (SRS-A) (IC50 = 10 µM).2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goetz, J.M., Sprecher, H., Cornwell, D.G., et al. Inhibition of prostaglandin biosynthesis by triynoic acids. Prostaglandins 12(2), 187-192 (1976).

    2. Sun, F.F., McGuire, J.C., Morton, D.R., et al. Inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds. Prostaglandins 21(2), 333-343 (1981).

    3. Jakschik, B.A., DiSantis, D.M., Sankarappa, S.K., et al. Modulation of leukotriene formation by various acetylenic acids. Leukotrienes and Other Lipoxygenase Products 127-135 (1982).