A fungal metabolite with diverse biological activities
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E-64

Item No. 10007963

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,3S)-3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid
CAS Number
66701-25-5
Molecular Formula
C15H27N5O5
Formula Weight
357.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/mlWater: 20 mg/ml
SMILES
NC(=N)NCCCCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(=O)O
InChi Code
InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11?/m0/s1
InChi Key
LTLYEAJONXGNFG-QRHSGQBVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    E-64 is a fungal metabolite originally isolated from Aspergillus japonicus that has diverse biological activities.1,2,3,4,5 It inhibits a variety of cysteine proteases, including cathepsins B, H, and L, as well as papain, ficin, and bromelain, but not the serine proteases plasmin, trypsin, and tissue kallikrein or the aspartic protease pepsin.2,1 E-64 (0.1-2 mg/ml) reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease.3 It is active against the FCR3 P. falciparum strain with an IC50 value of 836 nM.4 E-64 (5-25 µM) reduces bone resorption in embryonic mouse bone explants.5

    WARNING This product is not for human or veterinary use.