An internal standard for the quantification of 11(12)-DiHET
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Unlabeled Version(s)
51511(±)11(12)-DiHET
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(±)11(12)-DiHET-d11

Item No. 10007975

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(±)11,12-dihydroxy-5Z,11Z,14Z-eicosatrienoic-16,16,17,17,18,18,19,19,20,20,20-d11 acid
Synonyms
  • (±)11(12)-DHET-d11
  • (±)11,12-DiHETrE-d11
Molecular Formula
C20H23D11O4
Formula Weight
349.6
Purity
≥99% deuterated forms (d1-d11)
Formulation
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O[C@H](C/C=C\C/C=C\CCCC(O)=O)[C@H](O)C/C=C\C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
InChi Code
InChI=1S/C20H34O4/c1-2-3-4-5-9-12-15-18(21)19(22)16-13-10-7-6-8-11-14-17-20(23)24/h6,8-10,12-13,18-19,21-22H,2-5,7,11,14-17H2,1H3,(H,23,24)/b8-6-,12-9-,13-10-/t18-,19-/m1/s1/i1D3,2D2,3D2,4D2,5D2
InChi Key
LRPPQRCHCPFBPE-KENROLGJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 µg

    $201

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    50 µg

    $378

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    100 µg

    $712

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    250 µg

    $1,581

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    Product Description

    (±)11(12)-DiHET-d11 is intended for use as an internal standard for the quantification of 11(12)-DiHET by GC- or LC-MS. 11(S),12(S)-DiHET and 11(R),12(R)-DiHET are vicinal diols formed via enzymatic hydration of 11(12)-EET by cytosolic or soluble epoxide hydrolases in a non-stereoselective manner.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fang, X., Kaduce, T.L., Weintraub, N.L., et al. Functional implications of a newly characterized pathway of 11,12-epoxyeicosatrienoic acid metabolism in arterial smooth muscle. Circ. Res. 79(4), 784-793 (1996).

    2. Zeldin, D.C., Kobayashi, J., Falck, J.R., et al. Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase. The Journal of Biological Chemisty 268(9), 6402-6407 (1993).

    3. Zhang, G., Kodani, S., and Hammock, B.D. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer. Prog. Lipid Res. 53, 108-123 (2014).