A small-molecule inhibitor of TNF-α activity
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SPD-304

Item No. 10008012

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-4H-1-benzopyran-4-one
CAS Number
869998-49-2
Molecular Formula
C32H32F3N3O2
Formula Weight
547.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
209, 252, 299 nm
SMILES
CN(CCN(C)Cc1cn(c2cccc(c2)C(F)(F)F)c2ccccc12)Cc1coc2cc(C)c(C)cc2c1=O
InChi Code
InChI=1S/C32H32F3N3O2/c1-21-14-28-30(15-22(21)2)40-20-24(31(28)39)18-37(4)13-12-36(3)17-23-19-38(29-11-6-5-10-27(23)29)26-9-7-8-25(16-26)32(33,34)35/h5-11,14-16,19-20H,12-13,17-18H2,1-4H3
InChi Key
JZNXLPPJRFFECJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $33

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    1 mg

    $62

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    5 mg

    $248

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    10 mg

    $432

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    Product Description

    SPD-304 is an inhibitor of tumor necrosis factor α (TNF-α). that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM.1 It binds to the biologically active TNF-α trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. He, M.M., Smith, A.S., Oslob, J.D., et al. Small-molecule inhibition of TNF-α. Science 310, 1022-1025 (2005).

    Product Citations

    Kochukov, M.Y., McNearney, T.A., Yin, H., et al. Tumor necrosis factor-alpha (TNF-a) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes. Mol. Pain 5(49), (2009).