A synthetic phosphatidylinositol for signal transduction research
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PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt)

Item No. 10008115

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(1,2-dihexadecanoylphosphatidyl)inositol-4,5-bisphosphate, trisodium salt
CAS Number
1628353-01-4
Synonyms
  • DPPI-4,5-P2
  • Phosphatidylinositol-4,5-diphosphate C-16
  • PI(4,5)P2 (16:0/16:0)
  • PIP2[4',5'](16:0/16:0)
Molecular Formula
C41H78O19P3 • 3Na
Formula Weight
1036.9
Purity
≥98%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Chloroform: 0.1 mg/mlChloroform:Methanol:Water (3:3:1): 1 mg/mlWater: 10 mg/ml
SMILES
O=C(OC[C@H](COP(O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@H]1O)([O-])=O)OC(CCCCCCCCCCCCCCC)=O)CCCCCCCCCCCCCCC.[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C41H81O19P3.3Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(42)55-31-33(57-35(43)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)32-56-63(53,54)60-39-36(44)37(45)40(58-61(47,48)49)41(38(39)46)59-62(50,51)52;;;/h33,36-41,44-46H,3-32H2,1-2H3,(H,53,54
InChi Key
STJBVCQNLFXTFJ-OXJUOGSOSA-K
Side Chain Carbon Sum
32:0
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $82

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    500 µg

    $363

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    1 mg

    $642

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    Product Description

    The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns PtdIns-(4,5)-P2 (1,2-dipalmitoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) containing C16:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. The natural compound is the product of PtdIns-4-phosphate 5-kinase acting on PtdIns-(4)-P1. Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu. Rev. Pharmacol. Toxicol. 36, 481-509 (1996).

    2. Majerus, P.W. Inositol phosphate biochemistry. Annu. Rev. Biochem. 61, 225-250 (1992).