A selective enhancer of AR degradation
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Isomer(s)
10009986Dimethoxycurcumin
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Dimethylcurcumin

Item No. 10008187

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1E,4Z)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6E-heptatrien-3-one
CAS Number
52328-98-0
Molecular Formula
C23H24O6
Formula Weight
396.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH7.2) (1:2): 0.30 mg/mlDMSO: 5 mg/mlEthanol: 0.25 mg/ml
λmax
264, 419 nm
SMILES
COC1=CC=C(/C=C/C(/C=C(O)/C=C/C2=CC(OC)=C(OC)C=C2)=O)C=C1OC
InChi Code
InChI=1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-15,24H,1-4H3/b9-5+,10-6+,18-15-
InChi Key
ZMGUKFHHNQMKJI-CIOHCNBKSA-N
Origin
Plant/Zingiber officinale Rose
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

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    10 mg

    $376

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    25 mg

    $702

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    Product Description

    Dimethylcurcumin is a selective enhancer of androgen receptor (AR) degradation. By disrupting the interaction between AR and its coregulators, dimethylcurcumin directs the degradation of AR and reduces signaling through this receptor both in cultured cells and in animals.1,2,3 In this way, dimethylcurcumin suppresses the growth of hepatocellular carcinoma (HCC) cells both in culture and in mice.2 Dimethylcurcumin can be used to elucidate the consequences of signaling through AR in various cell types.1,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lai, J.-J., Lai, K.-P., Chuang, K.-H., et al. Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-α expression. J. Clin. Invest. 119(12), 3739-3751 (2009).

    2. Ma, W.-L., Hsu, C.-L., Wu, M.-H., et al. Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma. Gastroenterology 135(3), 947-955 (2008).

    3. Yang, Z., Chang, Y.-J., Yu, I.-C., et al. ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat. Med. 13(3), 348-353 (2007).

    4. Wen, S., Niu, Y., Lee, S.O., et al. Targeting fatty acid synthase with ASC-J9 suppresses proliferation and invasion of prostate cancer cells. Mol. Carcinog. 55(12), 2278-2290 (2016).

    5. Xu, J., Lin, H., Li, G., et al. Sorafenib with ASC-J9® synergistically suppresses the HCC progression via altering the pSTAT3-CCL2/Bcl2 signals. Int. J. Cancer 140(3), 705-717 (2017).

    Product Citations

    Badders, N.M., Korff, A., Miranda, H.C., et al. Selective modulation of the androgen receptor activation function-2-domain rescues degeneration in spinal bulbar muscular atrophy. Nat. Med. 24(4), 427-437 (2018).