An antitumor benzothiazole
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Product Type

Biochemicals

Research Area

Cancer

GW 610

Item No. 10008313

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dimethoxyphenyl)-5-fluoro-benzothiazole
CAS Number
872726-44-8
Synonyms
  • NSC 721648
Molecular Formula
C15H12FNO2S
Formula Weight
289.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 0.5 mg/ml
λmax
223, 324 nm
SMILES
COc1cc(ccc1OC)c1nc2cc(F)ccc2s1
InChi Code
InChI=1S/C15H12FNO2S/c1-18-12-5-3-9(7-13(12)19-2)15-17-11-8-10(16)4-6-14(11)20-15/h3-8H,1-2H3
InChi Key
ZRLSVQBGBBYEAZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $25

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    5 mg

    $105

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    10 mg

    $184

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    50 mg

    $796

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    Product Description

    GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0.1 nM) was observed.1 Potent and selective activity was also observed in the NCI 60 human cancer cell line panel. In contrast with previously reported 2-(4-aminophenyl)benzothiazoles, GW 610 is not reliant on induction of cytochrome P 1A1 (CYP1A1) expression for antitumor activity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mortimer, C.G., Wells, G., Crochard, J.P., et al. Antitumor benzothiazoles. 26. 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. J. Med. Chem. 49(1), 179-185 (2006).