α-Eleostearic Acid methyl ester

9Z,11E,13E-octadecatrienoic acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil.¹ α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats.² It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ.¹ In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC₅₀ of 20 µM.² It also inhibits DNA polymerases and topoisomerases with IC₅₀s ranging from ~5-20 µM for different isoforms of the enzymes.³ α-ESA methyl ester is a neutral, more lipid soluble form of the free acid. [Matreya, LLC. Catalog No. 1233]

WARNING This product is not for human or veterinary use.

1. Yasui, Y., Hosokawa, M., Sahara, T., et al. Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer caco-2 cells. Prostaglandins Leukot. Essent. Fatty Acids 73(2), 113-119 (2005).

2. Tsuzuki, T., Tokuyama, Y., Igarashi, M., et al. Tumor growth suppression by a α-eleostearic acid, linolenic acid isomer with a conjugated triene system, via lipid peroxidation. Carcinogenesis 25(8), 1417-1425 (2004).

3. Mizushina, Y., Tsuzuki, T., Eitsuka, T., et al. Inhibitory action of conjugated C₁₈-fatty acids on DNA polymerases and DNA topoisomerases. Lipids 39(10), 977-983 (2004).

Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).