α-Eleostearic Acid ethyl ester

α-Eleostearic Acid ethyl ester (α-ESA ethyl ester) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil.¹ α-ESA ethyl ester is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats.² It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA ethyl ester induced apoptosis through up-regulation of GADD45, p53, and PPARγ.¹ In DLD-1 cells supplemented with α-ESA ethyl ester, apoptosis was induced via lipid peroxidation with an EC₅₀ of 20 µM.² It also inhibits DNA polymerases and topoisomerases with IC₅₀s ranging from ~5-20 µM for different isoforms of the enzymes.³ α-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.

WARNING This product is not for human or veterinary use.

1. Yasui, Y., Hosokawa, M., Sahara, T., et al. Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer caco-2 cells. Prostaglandins Leukot. Essent. Fatty Acids 73(2), 113-119 (2005).

2. Tsuzuki, T., Tokuyama, Y., Igarashi, M., et al. Tumor growth suppression by a α-eleostearic acid, linolenic acid isomer with a conjugated triene system, via lipid peroxidation. Carcinogenesis 25(8), 1417-1425 (2004).

3. Mizushina, Y., Tsuzuki, T., Eitsuka, T., et al. Inhibitory action of conjugated C₁₈-fatty acids on DNA polymerases and DNA topoisomerases. Lipids 39(10), 977-983 (2004).

Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).