α-Tocotrienol

α-Tocotrienol is an antioxidant and a form of vitamin E that has been found in rice bran and has neuroprotective properties.^1,2,3,4 It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.² Cytosolic microinjection of α-tocotrienol prevents glutamate-induced cell death and phosphorylation of 12-lipoxygenase (12-LO) in HT4 neurons.³ It reduces glutamate-induced cytosolic and mitochondrial production of reactive oxygen species (ROS), accumulation of N-terminally truncated Bcl-xL (ΔN-Bcl-xL), and cell death in primary rat hippocampal neurons.⁴ α-Tocotrienol (50 mg/kg) reduces infarct size in a spontaneously hypertensive rat model of stroke induced by tandem right common carotid artery and middle cerebral artery occlusion.³ [Matreya, LLC. Catalog No. 2109]

WARNING This product is not for human or veterinary use.

1. Kamal-Eldin, A., and Appelqvist, L.-Å. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31(7), 671-701 (1996).

2. Osakada, F., Hashino, A., Kume, T., et al. α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology 47(6), 904-915 (2004).

3. Khanna, S., Roy, S., Slivka, S., et al. Neuroprotective properties of the natural vitamin E α-tocotrienol. Stroke 36, 2258-2264 (2005).

4. Park, H.-A., Mnatsakanyan, N., Broman, K., et al. Alpha-tocotrienol prevents oxidative stress-mediated post-translational cleavage of Bcl-xL in primary hippocampal neurons. Int. J. Mol. Sci. 21(1), 220 (2020).

Park, H.-A., Mnatsakanyan, N., Broman, K., et al. Alpha-tocotrienol prevents oxidative stress-mediated post-translational cleavage of Bcl-xL in primary hippocampal neurons. Int. J. Mol. Sci. 21(1), 220 (2020).