Synthetic, pure phosphoinositol for signal transduction research
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D-myo-Inositol-4,5-diphosphate (sodium salt)

Item No. 10008418

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
D-myo-inositol-4,5-di(hydrogen phosphate), disodium salt
Synonyms
  • Ins(4,5)-P2 (sodium salt)
  • 4,5-IP2 (sodium salt)
Molecular Formula
C6H12O12P2 • 2Na
Formula Weight
384.1
Purity
≥98%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 50 mg/ml
SMILES
O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H](O)[C@H]1O.[Na+].[Na+]
InChi Code
InChI=1S/C6H14O12P2.2Na/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13;;/h1-10H,(H2,11,12,13)(H2,14,15,16);;/q;2*+1/p-2/t1-,2+,3-,4-,5?,6?;;/m0../s1
InChi Key
AGYHIHUTKCMLKM-GFRJWRMMSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

    $69

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    500 µg

    $297

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    1 mg

    $525

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    Product Description

    D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a key second messenger produced in cells by PLC-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate.1,2 Binding of Ins(1,4,5)P3 to one of several Ins(1,4,5)P3 receptors results in opening of the calcium channels and an increase in intracellular calcium.2,3 Ins(4,5)P2 is a metabolite of Ins(1,4,5)P3 that lacks a phosphate at the 1' position. Ins(4,5)P2 formation has been reported as an intermediate in the metabolism Ins(1,4,5)P3 in GH3 pituitary cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Streb, H., Irvine, R.F., Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306(5938), 67-69 (1983).

    2. Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn. J. Pharmacol. 74(2), 125-137 (1997).

    3. Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu. Rev. Pharmacol. Toxicol. 36, 481-509 (1996).

    4. Ruiz-Larrea, F., and Drummond, A.H. Pathways of dephosphorylation of 1-D-myo-inositol 1,4,5-trisphosphate in GH3 pituitary tumor cells. Biochim. Biophys. Acta 1178, 63-72 (1993).