A synthetic, pure inositol phosphate for signal transduction research
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D-myo-Inositol-1,2,4,5-tetraphosphate (sodium salt)

Item No. 10008451

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
D-myo-inositol-1,2,4,5-tetrakis(dihydrogen phosphate), tetrasodium salt
Synonyms
  • Ins(1,2,4,5)P4
  • 1,2,4,5-IP4
Molecular Formula
C6H12O18P4• 4Na
Formula Weight
588.0
Purity
≥98%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 50 mg/ml
SMILES
O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H](OP([O-])(O)=O)[C@H]1OP([O-])(O)=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C6H16O18P4.4Na/c7-1-3(21-25(9,10)11)5(23-27(15,16)17)2(8)6(24-28(18,19)20)4(1)22-26(12,13)14;;;;/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);;;;/q;4*+1/p-4/t1-,2-,3?,4?,5?,6?;;;;
InChi Key
GPEDWSWFXATPAL-ZGXJPNOWSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

    $149

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    500 µg

    $669

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    1 mg

    $1,188

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    Product Description

    D-myo-Inositol-1,2,4,5-tetraphosphate (Ins(1,2,4,5)P4) is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals.1,2,3 Ins(1,2,4,5)P4 exhibits agonist activity at the Ins(1,4,5)P3 receptor expressed in CHO cells where it induces Ca2+ mobilization with an ED50 value of 0.22 µM, making it nearly equipotent to Ins(1,4,5)P3 (EC50 = 0.1 µM) in the same assay.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361(6410), 315-325 (1993).

    2. Majerus, P.W. Inositol phosphate biochemistry. Annu. Rev. Biochem. 61, 225-250 (1992).

    3. Shears, S.B. The versatility of inositol phosphates as cellular signals. Biochim. Biophys. Acta 1436(1-2), 49-67 (1998).

    4. Burford, N.T., Nahorski, S.R., Chung, S.K., et al. Binding and activity of the nine possible regioisomers of myo-inositol tetrakisphosphate at the inositol 1,4,5-trisphosphate receptor. Cell Calcium 21, 301-310 (1997).