A form of vitamin E with diverse biological activities
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Isomer(s)
9001533β-Tocotrienol
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γ-Tocotrienol

Item No. 10008494

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl]-2H-1-benzopyran-6-ol
CAS Number
14101-61-2
Molecular Formula
C28H42O2
Formula Weight
410.6
Purity
≥98%
Formulation (Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
297 nm
SMILES
C[C@]1(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)OC2=C(C)C(C)=C(O)C=C2CC1
InChi Code
InChI=1S/C28H42O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h11,13,15,19,29H,8-10,12,14,16-18H2,1-7H3/b21-13+,22-15+/t28-/m1/s1
InChi Key
OTXNTMVVOOBZCV-WAZJVIJMSA-N
Origin
Plant/Elaeis guineensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    25 mg

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    Product Description

    γ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.1,2 It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.2 γ-Tocotrienol (20 µM) induces apoptosis in malignant sympathoadrenal (+SA) mouse mammary epithelial cells.3 In vivo, γ-tocotrienol (15, 30, and 150 mg/kg) reduces blood pressure and plasma lipid peroxide levels in spontaneously hypertensive rats.4 [Matreya, LLC. Catalog No. 2111]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kamal-Eldin, A., and Appelqvist, L.-Å. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31(7), 671-701 (1996).

    2. Osakada, F., Hashino, A., Kume, T., et al. α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology 47(6), 904-915 (2004).

    3. Shah, S., and Sylvester, P.W. Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells. Exp. Biol. Med. (Maywood) 229(8), 745-755 (2004).

    4. Newaz, M.A., Yousefipour, Z., Nawal, N., et al. Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: Antioxidant protection by γ-tocotrienol. J. Physiol. Pharmacol. 54(3), 319-327 (2003).

    Product Citations

    Kuhn, M.J., and Sordillo, L.M. Inhibition of 20-hydroxyeicosatetraenoic acid biosynthesis by vitamin E analogs in human and bovine cytochrome P450 microsomes. J. Anim. Physiol. Anim. Nutr. (Berl.) 1-6 (2021).

    Kuhn, M.J., and Sordillo, L.M. Vitamin E analogs limit in vitro oxidant damage to bovine mammary endothelial cells. J. Dairy Sci. 104(6), 7154-7167 (2021).