An epimer of PTA2
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15(R)-Pinane Thromboxane A2

Item No. 10008510

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5Z)-7-[(1S,2R,3R,5S)-3-[(1E,3R)-3-hydroxy-1-octen-1-yl]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-5-heptenoic acid
CAS Number
71154-83-1
Synonyms
  • 15-epi-Pinane Thromboxane A2
  • 15-iso-Pinane Thromboxane A2
  • 15(R)-PTA2
  • 15-epi-PTA2
  • 15-iso-PTA2
Molecular Formula
C24H40O3
Formula Weight
376.6
Purity
≥98%
Formulation (Request formulation change)
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 25 mg/mlEthanol: 100 mg/mlPBS (pH 7.2): .15 mg/ml
SMILES
CCCCC[C@@H](O)/C=C/[C@H]1C[C@H]2C[C@H](C2(C)C)[C@@H]1C/C=C\CCCC(O)=O
InChi Code
InChI=1S/C24H40O3/c1-4-5-8-11-20(25)15-14-18-16-19-17-22(24(19,2)3)21(18)12-9-6-7-10-13-23(26)27/h6,9,14-15,18-22,25H,4-5,7-8,10-13,16-17H2,1-3H3,(H,26,27)/b9-6-,15-14+/t18-,19-,20+,21+,22-/m0/s1
InChi Key
OHJIHGVLRDHSDV-PUYXBYOHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $53

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    1 mg

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    5 mg

    $423

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    10 mg

    $740

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    Product Description

    15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 (PTA2; Item No. 19020). 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 µM).1 It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 µg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Caton, M.P.L., Stuttle, K.A.J., Tuffin, D.P., et al. Comparative action of carbocyclic thromboxane A2 stereoisomers on platelets. Eur. J. Med. Chem. 35(12), 1099-1107 (2000).

    2. Bennett, A., and Sanger, G.J. Pinane thromboxane A2 analogues are non-selective prostanoid antagonists in rat and human stomach muscle. Br. J. Pharmacol. 77(4), 591-596 (1982).