CYP3A metabolite of testosterone
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6β-hydroxy Testosterone

Item No. 10008519

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6β,17β-androst-4-en-3-one
CAS Number
62-99-7
Synonyms
  • 4-Androsten-6β,17β-diol-3-one
  • 6β, 17β,-Dihydroxyandrost-4-en-3-one
Molecular Formula
C19H28O3
Formula Weight
304.4
Purity
≥97%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: 1 mg/mlEthanol: 1 mg/mlMethanol: 1 mg/ml
λmax
236 nm
SMILES
C[C@@]12[C@](CC[C@@H]2O)([H])[C@]3([H])C[C@@H](O)C4=CC(CC[C@]4(C)[C@@]3([H])CC1)=O
InChi Code
InChI=1S/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1
InChi Key
XSEGWEUVSZRCBC-ZVBLRVHNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $142

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    Product Description

    CYP3A4 and CYP3A5 are cytochrome P450 enzymes whose expression is induced by glucocorticoids and certain xenobiotics, including many drugs and chemical carcinogens.1 They mediate the metabolism of xenobiotics as well as certain endobiotics, including steroid hormones.2 6β-hydroxy Testosterone is a major metabolite produced from testosterone by the actions of CYP3A4 and CYP3A5, accounting for 75-80% of all metabolites formed from testosterone.2,3 The biological effects of 6β-hydroxy testosterone have been poorly studied.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cooper, B.W., Cho, T.M., Thompson, P.M., et al. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression. Toxicol. Sci. 103(2), 268-277 (2008).

    2. Draper, A.J., Madan, A., Smith, K., et al. Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes. Drug Metab. Dispos. 26(4), 299-304 (1998).

    3. Capdevila, J.H., Karara, A., Waxman, D.J., et al. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. The Journal of Biological Chemisty 265(19), 10865-10871 (1990).

    Product Citations

    Husain, A., Riyazuddin, M., Katekar, R., et al. Herb-drug interaction studies of ethanolic extract of Cassia occidentalis L. coadministered with acetaminophen, theophylline, omeprazole, methotrexate and methylprednisolone. Phytomedicine Plus 1, 100008 (2021).