A fluorescent substrate for sEH
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Epoxy Fluor 7

Item No. 10008610

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyano(6-methoxy-2-napthalenyl)methyl[(2,3)-3-phenyloxiranyl]methyl ester, carbonic acid
CAS Number
863223-43-2
Synonyms
  • CMNPC
Molecular Formula
C23H19NO5
Formula Weight
389.4
Purity
≥98%
Emission
465 nm
Excitation
330 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
234 nm
SMILES
N#CC(OC(OCC(O1)C1C2=CC=CC=C2)=O)C3=CC4=CC=C(OC)C=C4C=C3
InChi Code
InChI=1S/C23H19NO5/c1-26-19-10-9-16-11-18(8-7-17(16)12-19)20(13-24)29-23(25)27-14-21-22(28-21)15-5-3-2-4-6-15/h2-12,20-22H,14H2,1H3
InChi Key
HDHFVICVWRKCHQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Epoxy fluor 7 is a fluorescent substrate for soluble epoxide hydrolase (sEH).1,2 Upon hydrolysis by sEH, the resulting diol undergoes cyclization and decomposition to a fluorescent aldehyde product, 6-methoxy-2-naphthaldehyde, which can be used to quantify the activity of purified human or mouse sEH. 6-Methoxy-2-naphthaldehyde displays excitation/emission maxima of 330/465 nm, respectively. Epoxy fluor 7 is intended for use with purified sEH or a preparation free of competing enzyme activities, such as esterase and glutathione S-transferase activity, and can be used for high-throughput screening.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jones, P.D., Wolf, N.M., Morisseau, C., et al. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. Anal. Biochem. 343(1), 66-75 (2005).

    2. Morisseau, C., and Hammock, B.D. Measurement of soluble epoxide hydrolase (sEH) activity. Curr. Protoc. Toxicol. 4.23.2(Suppl. 33), (2007).

    Product Citations

    Morisseau, C., and Hammock, B.D. Measurement of soluble epoxide hydrolase (sEH) activity. Curr. Protoc. Toxicol. 4.23.2(Suppl. 33), (2007).