A CYP3A metabolite of testosterone
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11α-hydroxy Testosterone

Item No. 10008647

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11α,17β-dihydroxy-androst-4-en-3-one
CAS Number
3066-12-4
Molecular Formula
C19H28O3
Formula Weight
304.4
Purity
≥97%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 1 mg/ml
λmax
241 nm
SMILES
O[C@H]1CC[C@@]2([H])[C@]3([H])CCC([C@@](CC4)(C)[C@@]3([H])[C@H](O)C[C@@]21C)=CC4=O
InChi Code
InChI=1S/C19H28O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14,2)10-15(21)17(13)18/h9,13-17,21-22H,3-8,10H2,1-2H3/t13-,14-,15+,16-,17+,18-,19-/m0/s1
InChi Key
YQDZGFAYWGWSJK-RUOITVIXSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    11α-hydroxy Testosterone is a metabolite of testosterone, produced by the cytochrome P450 (CYP) isoform CYP3A.1 It can also be generated from testosterone by a mutant of CYP107A1 and from 11α-hydroxy progesterone by the fungus B. bassiana.2,3 The biological activity of this metabolite has not been elucidated.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, Q., and Li, Z. Synthesis of 11-substituted androstenediones and testosterones as human decidual cell growth inhibitors. Steroids 59(3), 190-195 (1994).

    2. Xiang, H., Tschirret-Guth, R.A., and Ortiz de Montellano, P.R. An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates. The Journal of Biological Chemisty 275(46), 35999-36006 (2000).

    3. Swizdor, A., Kolek, T., Panek, A., et al. Microbial Baeyer-Villiger oxidation of steroidal ketones using Beauveria bassiana: Presence of an 11α-hydroxyl group essential to generation of D-homo lactones. Biochim. Biophys. Acta 1811(4), 253-262 (2011).