A potent inhibitor of cPLA2α
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CAY10502

Item No. 10008657

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-1H-indole-3,5-dicarboxylic acid, 3-methyl ester
CAS Number
888320-29-4
Molecular Formula
C30H37NO7
Formula Weight
523.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/ml
λmax
236, 289 nm
SMILES
O=C(COC1=CC=C(OCCCCCCCCCC)C=C1)CN2C3=CC=C(C(O)=O)C=C3C(C(OC)=O)=C2
InChi Code
InChI=1S/C30H37NO7/c1-3-4-5-6-7-8-9-10-17-37-24-12-14-25(15-13-24)38-21-23(32)19-31-20-27(30(35)36-2)26-18-22(29(33)34)11-16-28(26)31/h11-16,18,20H,3-10,17,19,21H2,1-2H3,(H,33,34)
InChi Key
NXDZVUAKVFVDSL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $50

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    1 mg

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    5 mg

    $297

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    Product Description

    CAY10502 is a potent inhibitor of calcium-dependent cytosolic PLA2α (cPLA2α) with an IC50 value of 4.3 nM for the purified enzyme from human platelets.1 It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ludwig, J., Bovens, S., Brauch, C., et al. Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2α. J. Med. Chem. 49(8), 2611-2620 (2006).

    Product Citations

    Leis, H.J., and Windischhofer, W. Phospholipase D1 activity is crucial for cytosolic phospholipase A2 -dependent prostaglandin E2 formation in murine osteoblastic MC3T3-E1 cells. Prostaglandins Leukot. Essent. Fatty Acids 198-199, 102592 (2023).