A potent, irreversible FAAH inhibitor
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JP83

Item No. 10008660

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3'-carbamoyl-biphenyl-3-yl-hexylphenylcarbamate
CAS Number
887264-44-0
Molecular Formula
C26H28N2O3
Formula Weight
416.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.25 mg/mlEthanol: 1 mg/ml
SMILES
O=C(NCCCCCCc1ccccc1)Oc1cccc(c1)c1cccc(c1)C(=O)N
InChi Code
InChI=1S/C26H28N2O3/c27-25(29)23-15-8-13-21(18-23)22-14-9-16-24(19-22)31-26(30)28-17-7-2-1-4-10-20-11-5-3-6-12-20/h3,5-6,8-9,11-16,18-19H,1-2,4,7,10,17H2,(H2,27,29)(H,28,30)
InChi Key
JMLPLSJWSHVJLP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $42

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    10 mg

    $79

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    50 mg

    $322

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    Product Description

    JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor of the carbamate class with an IC50 of 14 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alexander, J.P., and Cravatt, B.F. Mechanism of carbmate inactivation of FAAH: Implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chem. Biol. 12, 1179-1187 (2005).