An irreversible FAAH inhibitor
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JP104

Item No. 10008661

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-10-undecyn-1-yl-carbamic acid, 3’-(aminocarbonyl)[1,1’-biphenyl]-3-yl ester
CAS Number
887264-45-1
Synonyms
  • Click Tag™ JP104
Molecular Formula
C25H30N2O3
Formula Weight
406.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): .25 mg/mlEthanol: 1 mg/ml
SMILES
NC(C1=CC(C2=CC=CC(OC(NCCCCCCCCCC#C)=O)=C2)=CC=C1)=O
InChi Code
InChI=1S/C25H30N2O3/c1-2-3-4-5-6-7-8-9-10-17-27-25(29)30-23-16-12-14-21(19-23)20-13-11-15-22(18-20)24(26)28/h1,11-16,18-19H,3-10,17H2,(H2,26,28)(H,27,29)
InChi Key
BCKBOXGAYIOHDQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $50

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    10 mg

    $94

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    50 mg

    $387

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    100 mg

    $676

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    Product Description

    JP104 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor of the carbamate class with an IC50 of 7.3 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate.1 The alkyl derivative on JP104 reacts with azide-modified reporter tags, such as azido-rhodamine or azido-biotin, for visualization of JP104 bound to FAAH in vivo.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alexander, J.P., and Cravatt, B.F. Mechanism of carbmate inactivation of FAAH: Implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chem. Biol. 12, 1179-1187 (2005).