- A specific assay for domoic acid, a neurotoxin responsible for ASP
- Amnesic shellfish poison ELISA Kit
- ASP ELISA Kit
Domoic acid (DA) and DA derivatives are water-soluble neurotoxins produced by a number of marine algae, in particular those of the genus Pseudo-nitzschia. Blooms of Pseudo-nitzschia may lead to the accumulation of DA in shellfish filter feeders and other marine species. Ingestion of DA-contaminated shellfish causes amnesic shellfish poisoning (ASP) and has been linked to the death of animal and human consumers in severe cases. The European Commission Directive 2002/226/EC has implemented a maximum permitted level (MPL) of 20 mg DA/kg shellfish flesh intended for human consumption, and this level has been adopted by regulatory authorities in most other countries. The ASP ELISA is specific for DA with no cross-reactivity to non-toxic, structural analogues like kainic acid, L-glutamic acid, L-glutamine, formimino-L-glutamic acid, proline or γ-aminobutyric acid (GABA). The assay is primarily intended for use in routine monitoring of DA levels in bivalve molluscs to comply with the regulatory MPL, but is also applicable for DA quantification in other marine matrices.