A selective estrogen receptor α agonist
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Propylpyrazole Triol

Item No. 10008841

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris-phenol
CAS Number
263717-53-9
Synonyms
  • PPT
Molecular Formula
C24H22N2O3
Formula Weight
386.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.15 mg/mlEthanol: 10 mg/ml
λmax
255 nm
SMILES
OC1=CC=C(C=C1)N2C(C3=CC=C(O)C=C3)=C(CCC)C(C4=CC=C(O)C=C4)=N2
InChi Code
InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3
InChi Key
IOTXSIGGFRQYKW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $24

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    5 mg

    $98

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    10 mg

    $173

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    25 mg

    $376

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    Product Description

    Propylpyrazole triol (PPT) is an ERα selective agonist with a 410-fold relative binding affinity for ERα (49%) versus ERβ (0.12%) and therefore activates gene transcription only through ERα.1,2 In an in vivo rabbit model of ischemia-reperfusion injury, treatment with estradiol and PPT, but not diarylpropinitrile (a selective agonist of ERβ) significantly decreased the infarct size compared with vehicle.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stauffer, S.R., Coletta, C.J., Tedesco, R., et al. Pyrazole ligands: Structure-affinity/activity relationships and estrogen receptor-α-selective agonists. J. Med. Chem. 43, 4934-4947 (2000).

    2. Meyers, M.J., Sun, J., Carlson, K.E., et al. Estrogen receptors-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogus. J. Med. Chem. 44, 4230-4251 (2001).

    3. Booth, E.A., Obeid, N.R., and Lucchesi, B.R. Activation of estrogen receptor-α protects the in vivo rabbit heart from ischemia-reperfusion injury. Am. J. Physiol. 289, H2039-H2047 (2005).