An estrogen receptor β agonist
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2,3-bis (4-Hydroxyphenyl) Propionitrile

Item No. 10008842

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-α-(4-hydroxyphenyl)-benzenepropanenitrile
CAS Number
1428-67-7
Synonyms
  • DPN
Molecular Formula
C15H13NO2
Formula Weight
239.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2)(1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
230, 270 nm
SMILES
NCC(Cc1ccc(O)cc1)c1ccc(O)cc1
InChi Code
InChI=1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
InChi Key
GHZHWDWADLAOIQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $43

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    10 mg

    $81

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    50 mg

    $333

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    100 mg

    $580

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    Product Description

    2,3-bis (4-Hydroxyphenyl)propionitrile (DPN) is an estrogen receptor β (ERβ) selective agonist. DPN exhibits a 70-fold higher relative binding affinity for ERβ (18%) versus ERα (0.25%), about 80-fold higher transcriptional potency (EC50 = 0.85 nM versus 66 nM), and 170-fold higher relative potency (4.6% versus 0.025%) in transcription assays.1 Based on this selectivity, DPN is commonly used as a tool to evaluate the biological role of ERβ.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meyers, M.J., Sun, J., Carlson, K.E., et al. Estrogen receptors-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogus. J. Med. Chem. 44, 4230-4251 (2001).