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CAY10573

Item № 10008846
CAS № 853652-40-1
Purity ≥98%
product image
                (CAS 853652-40-1)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 µg $35.00 0.00
     1 mg $67.00 0.00
     5 mg $280.00 0.00
     10 mg $490.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 is a PPAR agonist that displays potent binding at PPARα, γ, and δ with IC50 values of 113, 50, and 223 nM, respectively. It potently transactivates PPARα, γ, and δ with EC50 values of 8, 70, and 500 nM, respectively.1 CAY10573 demonstrates stronger binding and functional activity for PPARγ than the antidiabetic compound rosiglitazone (IC50 = 92 nM; EC50 = 220 nM).1

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Technical Information
Formal Name
5-[3-[(6-benzoyl-1-propyl-2-naphthalenyl)oxy]propoxy]-1H-indole-1-acetic acid
CAS Number
853652-40-1
Molecular Formula
C33H31NO5
Formula Weight
521.6
Purity
≥98%
Formulation
A crystalline solid
λmax
227, 274 nm
SMILES
CCCc1c(OCCCOc2ccc3ccn(CC(=O)O)c3c2)ccc2cc(ccc12)C(=O)c1ccccc1
InChI Code
InChI=1S/C33H31NO5/c1-2-7-29-28-14-11-26(33(37)24-8-4-3-5-9-24)20-25(28)12-15-31(29)39-19-6-18-38-27-13-10-23-16-17-34(22-32(35)36)30(23)21-27/h3-5,8-17,20-21H,2,6-7,18-19,22H2,1H3,(H,35,36)
InChI Key
PMPUMRAPFFYFRW-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Mahindroo, N., Wang, C.C., Liao, C.C., et al. Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies Journal of Medicinal Chemistry 49, 1212-1216 (2006).

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