A PPAR pan-agonist
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CAY10573

Item No. 10008846

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[3-[(6-benzoyl-1-propyl-2-naphthalenyl)oxy]propoxy]-1H-indole-1-acetic acid
CAS Number
853652-40-1
Molecular Formula
C33H31NO5
Formula Weight
521.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.3 mg/mlDMSO: 0.5 mg/ml
λmax
227, 274 nm
SMILES
CCCc1c(OCCCOc2ccc3ccn(CC(=O)O)c3c2)ccc2cc(ccc12)C(=O)c1ccccc1
InChi Code
InChI=1S/C33H31NO5/c1-2-7-29-28-14-11-26(33(37)24-8-4-3-5-9-24)20-25(28)12-15-31(29)39-19-6-18-38-27-13-10-23-16-17-34(22-32(35)36)30(23)21-27/h3-5,8-17,20-21H,2,6-7,18-19,22H2,1H3,(H,35,36)
InChi Key
PMPUMRAPFFYFRW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $49

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    1 mg

    $93

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    5 mg

    $376

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    10 mg

    $655

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    Product Description

    CAY10573 is a PPAR agonist that displays potent binding at PPARα, γ, and δ with IC50 values of 113, 50, and 223 nM, respectively. It potently transactivates PPARα, γ, and δ with EC50 values of 8, 70, and 500 nM, respectively.1 CAY10573 demonstrates stronger binding and functional activity for PPARγ than the antidiabetic compound rosiglitazone (IC50 = 92 nM; EC50 = 220 nM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mahindroo, N., Wang, C.C., Liao, C.C., et al. Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies. J. Med. Chem. 49(3), 1212-1216 (2006).