A proapoptotic, antiproliferative compound
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Cycle
G1
Multidrug Resistance

CAY10503

Item No. 10008872

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-hydroxyphenyl)phenyl-3,5-benzenediol
CAS Number
890854-82-7
Molecular Formula
C18H14O3
Formula Weight
278.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2)(1:3): 0.25 mg/ml
λmax
207, 291 nm
SMILES
Oc1ccc(cc1)c1ccc(cc1)c1cc(O)cc(O)c1
InChi Code
InChI=1S/C18H14O3/c19-16-7-5-13(6-8-16)12-1-3-14(4-2-12)15-9-17(20)11-18(21)10-15/h1-11,19-21H
InChi Key
DADMQAUVBPTTDT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $31

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    5 mg

    $129

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    10 mg

    $228

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    50 mg

    $983

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    Cayman Chemical
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    Product Description

    CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase.1 CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of 7.0, 23, and 20 µM, respectively. Accumulation of HL60 cells in G0-G1 occurred within eight hours following treatment with 50 µM CAY10503, whereas 10 µM CAY10503 required 96 hours for cell cycle arrest to appear. CAY10503 also induces differentiation of HL60 cells into the following positive cells: CD14 (monocytic marker) as well as CD11b and CD11c (granulocytic markers). Approximately 60% of HL60 cells exposed to 10 µM CAY10503 expressed these markers within 72 hours.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roberti, M., Pizzirani, D., Recanatini, M., et al. Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J. Med. Chem. 49(10), 3012-3018 (2006).