Pricing updated 2019-05-26. Prices are subject to change without notice.
(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively.1 In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve.2 This effect is fully counteracted by rimonabant (Item No. 9000484) at a concentration of 10 nM, by decreasing Ca2+ concentrations below 0.2 mM, or by the IP3 receptor antagonist xestospongin C (Item No. 64950) at a concentration of 1 µM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 value of 26 µM.3
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1. Felder, C.C., Joyce, K.E., Briley, E.M., et al. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors Mol. Pharmacol. 48(3), 443-450 (1995).
Ferraro, L., Tomasini, M.C., Gessa, G.L., et al. The cannabinoid receptor agonist WIN 55,212-
Price, T.J., Patwardhan, A., Akopian, A.N., et al. Cannabinoid receptor-
Roberto, D., Klotz, L.H., and Venkateswaran, V. Cannabinoid WIN 55,212-