Antioxidant and ribonucleotide reductase inhibitor
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Didox

Item No. 10009081

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,3,4-tridhydroxy-benzamide
CAS Number
69839-83-4
Synonyms
  • NSC 324360
Molecular Formula
C7H7NO4
Formula Weight
169.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
209, 257, 291 nm
SMILES
ONC(=O)c1ccc(O)c(O)c1
InChi Code
InChI=1S/C7H7NO4/c9-5-2-1-4(3-6(5)10)7(11)8-12/h1-3,9-10,12H,(H,8,11)
InChi Key
QJMCKEPOKRERLN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $20

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    5 mg

    $81

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    10 mg

    $142

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    50 mg

    $609

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    Cayman Chemical
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    Product Description

    Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients with dementia.1 It also increases the radiosensitivity of cancer cells by inhibition of ribonucleotide reductase, resulting in a reduction of bcl-2 mediated resistance to apoptosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Turchan, J., Pocernich, C.B., Gairola, C., et al. Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. Neurology 60(2), 307-314 (2003).

    2. Inayat, M.S., Chendil, D., Mohiuddin, M., et al. Didox (A novel ribonucleotide reductase inhibitor) Overcomes bcl-2 mediated radiation resistance in prostate cancer cell line PC-3. Cancer Biol. Ther. 1(5), 539-545 (2002).