β-Catenin (Phospho-Ser^33,37) Polyclonal Antibody

β-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway.^1,2 The role of β-catenin in these processes is thought to be regulated by the sequential phosphorylation of Ser²⁹, Ser³³, Ser³⁷, and Thr⁴¹ by glycogen synthase kinase 3β (GSK3β).³ This hyperphosphorylation promotes the ubiquitylation and targeted destruction of β-catenin. Mutations in components of this phosphorylation-regulated process that prevent β-catenin hyperphosphorylation by GSK3β are strongly associated with cancers.^3,2,4

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1. Ding, Y., and Dale, T. Wnt signal transduction: Kinase cogs in a nano-machine? Trends Biochem. Sci. 27, 327-329 (2002).

2. Polakis, P. Wnt signaling and cancer. Genes Dev. 14(15), 1837-1851 (2000).

3. Liu, C., Li, Y., Semenov, M., et al. Control of ß-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108, 837-847 (2002).

4. Wang, Z.H., Vogelstein, B., and Kinzler, K.W. Phosphorylation of ß-catenin at S33, S37, or T41 can occur in the absense of phosphorylation at T45 in colon cancer cells. Cancer Res. 63, 5234-5235 (2003).