A PI4KIIIβ inhibitor
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PIK-93

Item No. 10009212

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-[4-chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]-acetamide
CAS Number
593960-11-3
Molecular Formula
C14H16ClN3O4S2
Formula Weight
389.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 0.25 mg/ml
λmax
203, 306 nm
SMILES
ClC1=C(S(NCCO)(=O)=O)C=C(C2=C(C)N=C(NC(C)=O)S2)C=C1
InChi Code
InChI=1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20)
InChi Key
JFVNFXCESCXMBC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $186

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    25 mg

    $378

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    Product Description

    PIK-93 is an inhibitor of phosphatidylinositol 4-kinase IIIβ (PI4KIIIβ; IC50 = 19 nM).1 It is selective for PI4KIIIβ over PI4KIIIα and PI4KIIα (IC50s = 1,100 and >100,000 nM, respectively). However, it also inhibits the PI3K catalytic subunits (IC50s = 39, 590, 120, and 16 nM for p110α, p110β, p110δ, and p110γ, respectively). PIK-93 reduces enteroviral RNA replication when used at a concentration of 125 nM in HeLa cells.2 It also inhibits the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Knight, Z.A., Gonzalez, B., Feldman, M.E., et al. A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling. Cell 125(4), 733-747 (2006).

    2. Hsu, N.Y., Ilnytska, O., Belov, G., et al. Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell 141(5), 799-811 (2010).

    3. Toth, B., Balla, A., Ma, H., et al. Phosphatidylinositol 4-kinase IIIβ regulates the transport of ceramide between the endoplasmic reticulum and Golgi. The Journal of Biological Chemisty 281(47), 36369-36377 (2006).

    Product Citations

    Leier, H.C., Weinstein, J.B., Kyle, J.E., et al. A global lipid map defines a network essential for Zika virus replication. Nat. Commun. 11(1), 3652 (2020).