Sphingosine Kinase Inhibitor 2 (CAS 312636-16-1) | Cayman Chemical
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Sphingosine Kinase Inhibitor 2

Item № 10009222
CAS № 312636-16-1
Purity ≥95%
product image
                (CAS 312636-16-1)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $32.00 0.00
     10 mg $61.00 0.00
     25 mg $144.00 0.00
     50 mg $256.00 0.00

Pricing updated 2018-10-20. Prices are subject to change without notice.

Description
Synonyms
  • SKI II
  • SPHK I2

Sphingosine kinase isoforms, SPHK 1 and SPHK 2 , catalyze the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.1,2,3 Sphingosine kinase inhibitor 2 is an inhibitor of sphingosine kinase 1 (SPHK1) with an IC50 value of 0.5 µM for non-ATP-competitive inhibition of human recombinant SPHK1.4 It is selective for SPHK1 over ERK2, PI3K, and PKCα at concentrations up to 60 µM. Sphingosine kinase inhibitor 2 inhibits proliferation of several cancer cell lines, including T-24, MCF-7, NCI/ADR, and MCF-7/VP (IC50s = 0.9-4.6 µM).

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Technical Information
Formal Name
4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-phenol
CAS Number
312636-16-1
Synonyms
  • SKI II
  • SPHK I2
Molecular Formula
C15H11ClN2OS
Formula Weight
302.8
Purity
≥95%
Formulation
A crystalline solid
λmax
259, 282 nm
SMILES
OC1=CC=C(N([H])C2=NC(C3=CC=C(Cl)C=C3)=CS2)C=C1
InChI Code
InChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)
InChI Key
ZFGXZJKLOFCECI-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Takuwa, Y., Takuwa, N., and Sugimoto, N. The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activities. J. Biochem. 131(6), 767-771 (2002).

2. Ishii, I., Fukushima, N., Ye, X., et al. Lysophospholipid receptors: Signaling and biology. Annu. Rev. Biochem. 73, 321-354 (2004).

3. Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochimica et Biophysica Acta 1582(1-3), 72-80 (2002).

4. French, K.J., Schrecengost, R.S., Lee, B.D., et al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Research 63, 5962-5969 (2003).

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