An inhibitor of voltage-gated calcium channels
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SKF 96365 (hydrochloride)

Item No. 10009312

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-1H-imidazole, monohydrochloride
CAS Number
130495-35-1
Molecular Formula
C22H26N2O3 • HCl
Formula Weight
402.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: MiscibleDMSO: MiscibleEthanol: MiscibleEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
226, 275 nm
SMILES
COC1=CC=C(C=C1)C(OCCCC2=CC=C(OC)C=C2)CN3C=NC=C3.Cl
InChi Code
InChI=1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H
InChi Key
FWLPKVQUECFKSW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $22

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    5 mg

    $94

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    10 mg

    $161

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    50 mg

    $702

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    Product Description

    SKF 96365 inhibits the receptor-mediated influx of calcium via voltage-gated calcium channels with an IC50 value of approximately 10 µM.1 It inhibits the acetylcholine-induced depolarization of circular smooth muscle in a dose-dependent manner at 3-50 µM.2 SKF 96365 can distinguish receptor-mediated release in platelets and neutrophils from the calcium release from internal stores. However, it does not distinguish between receptor-mediated and voltage-gated release.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Merritt, J.E., Armstrong, W.P., Benham, C.D., et al. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem. J. 271, 515-522 (1990).

    2. Hotta, A., Kim, Y.C., Kakamura, E., et al. Effects of inhibitors of nonselective cation channels on the acetylcholine-induced depolarization of circular smooth muscle from the guinea-pig stomach antrum. J. Smooth Muscle Res. 41(6), 313-327 (2005).