An in vitro procaspase-3 activator
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PAC-1

Item No. 10009317

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(phenylmethyl)-1-piperazineacetic acid, 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide
CAS Number
315183-21-2
Synonyms
  • Procaspase-activating Compound 1
Molecular Formula
C23H28N4O2
Formula Weight
392.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 5 mg/ml
λmax
283, 293, 328 nm
SMILES
C=CCc1cccc(/C=N\NC(=O)CN2CCN(CC2)Cc2ccccc2)c1O
InChi Code
InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)/b24-16+
InChi Key
YQNRVGJCPCNMKT-LFVJCYFKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Procaspase-activating compound 1 (PAC-1) is a procaspase-3 activator and a potential drug treatment in cancer cell lines with elevated levels of procaspase-3.1 PAC-1's effectiveness was found to be directly proportional to the procaspase-3 concentration present in cells. In cancer cells, PAC-1 had an IC50 value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue IC50 values of 3.2-8.5 µM were observed.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Putt, K.S., Chen, G.W., Pearson, J.M., et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat. Chem. Biol. 2(10), 543-550 (2006).