For immunochemical detection of the glycine receptor
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Glycine Receptor Polyclonal Antibody

Item No. 10009399

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Immunogen
peptide from N-terminal region of the α1-subunit of the rat glycine receptor
Formulation (Request formulation change)
Peptide affinity-purified antibody
Host
Rabbit
Applications
WB and IHC (frozen sections)
Species Reactivity
(+) Human glycine receptor(+) Mouse glycine receptor(+) Rat glycine receptor
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea

    $464

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    Product Description

    Glycine is an important inhibitory transmitter in the brain stem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission.1 The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin.2 The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins.3,4 These receptors have also been extremely useful in studies of synaptic clustering of receptors.5 The glycine receptor may also act in concert with an NMDAR subunit to form an excitatory receptor.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
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