A glucosinolate with antioxidant activity
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Glucoraphanin (potassium salt)

Item No. 10009445

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-thio-1-[5-(methylsulfinyl)-N-(sulfooxy)pentanimidate]-β-D-glucopyranose, potassium salt
Synonyms
  • 4-Methylsulfinylbutyl Glucosinolate
  • Sulforaphane Glucosinolate
Molecular Formula
C12H22NO10S3 • XK
Formula Weight
436.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
225 nm
SMILES
O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](S/C(CCCCS(C)=O)=N/OS([O-])(=O)=O)[C@@H]1O.[K+]
InChi Code
InChI=1S/C12H23NO10S3.K/c1-25(18)5-3-2-4-8(13-23-26(19,20)21)24-12-11(17)10(16)9(15)7(6-14)22-12;/h7,9-12,14-17H,2-6H2,1H3,(H,19,20,21);/q;+1/p-1/b13-8+;/t7-,9-,10+,11-,12+,25?;/m1./s1
InChi Key
XLJHNVPISVILLA-KVSKZACISA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $165

    Add

    5 mg

    $743

    Add

    10 mg

    $1,320

    Add
    Product Description

    Glucoraphanin is a glucosinolate that has been found in broccoli and has antioxidant activity.1,2,3 It is converted by gut microbiota to the antioxidant L-sulforaphane (Item No. 14797).1 Glucoraphanin (25 and 50 µM) reverses hydrogen peroxide-induced decreases in Nrf2-mediated, but not NF-κB-mediated, transcriptional activity in reporter assays using Caco-2 human intestinal epithelial cells.2 It also restores epithelial integrity in a transepithelial electrical resistance (TEER) assay, but does not affect chemokine release, catalase activity, or chemokine (C-C motif) ligand 2 (CCL2) release, in Caco-2 cells. Glucoraphanin (30 µM) prevents dexamethasone-induced apoptosis and restores oxidative balance by reducing dexamethasone-induced increases in catalase activity, superoxide levels, and protein carbonylation in C2C12 mouse myotubes in an in vitro model of sarcopenia.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mazarakis, N., Snibson, K., Licciardi, P.V., et al. The potential use of L-sulforaphane for the treatment of chronic inflammatory diseases: A review of the clinical evidence. Clin. Nutr. 39(3), 664-675 (2020).

    2. Sonzogni, E., Martinelli, G., Fumagalli, M., et al. In vitro insights into the dietary role of glucoraphanin and its metabolite sulforaphane in celiac disease. Nutrients 16(16), 2743 (2024).

    3. Micheli, L., Mitidieri, E., Turnaturi, C., et al. Beneficial effect of H2S-releasing molecules in an in vitro model of sarcopenia: Relevance of glucoraphanin. Int. J. Mol. Sci. 23(11), 5955 (2022).