Active, pure human recombinant enzyme
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HDAC6 (human, recombinant)

Item No. 10009465

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Purity
≥85% estimated by SDS-PAGE
Source
50 µg of full-length recombinant N-terminal GST-tagged protein expressed in Sf9 cells
Amino Acids
2-1215 (full length)
MW
159 kDa
Formulation (Request formulation change)
40 mM Tris-HCl, pH 8.0, 110 mM sodium chloride, with 2.2 mM potassium chloride, 0.04% Tween 20, 3 mM DTT, and 20% glycerol
UniProt Accession №
Q9UBN7
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    50 µg

    $600

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    Product Description

    HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation.1,2 Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, H.Y., Chen, C.S., Lin, S.P., et al. Targeting histone deacetylase in cancer therapy. Med. Res. Rev. 26(4), 397-413 (2006).

    2. Huang, L. Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J. Cell. Physiol. 209(3), 611-616 (2006).