A potential CYP450 metabolite of N-arachidonoyl-taurine
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20-hydroxy N-Arachidonoyl Taurine

Item No. 10009501

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
20-hydroxy-2-[(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)amino]-ethane sulfonic acid
Molecular Formula
C22H37NO5S
Formula Weight
427.6
Purity
≥95%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 0.5 mg/ml
SMILES
O=C(NCCS(=O)(O)=O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCCO
InChi Code
InChI=1S/C22H37NO5S/c24-20-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-22(25)23-19-21-29(26,27)28/h1,3-4,6-7,9-10,12,24H,2,5,8,11,13-21H2,(H,23,25)(H,26,27,28)/b3-1-,6-4-,9-7-,12-10-
InChi Key
YBPLVNUECXEPBH-DTLRTWKJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 µg

    $160

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    50 µg

    $304

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    100 µg

    $574

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    500 µg

    $2,540

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    Product Description

    Arachidonic acid is metabolized by cytochrome P450 (CYP450) 4A ω-hydroxylase to 20-HETE, which acts as a vasoconstrictor in the kidney and brain.1 During mass spectrometry lipidomics analysis of rat brain, a series of fatty acyl amides of taurine was discovered, of which arachidonoyl taurine is a prominent member.2 20-hydroxy N-Arachidonoyl taurine is a potential CYP450 metabolite of N-arachidonoyl taurine and may activate members of the transient receptor potential (TRP) family of calcium channels.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McGiff, J.C., and Quilley, J. 20-HETE and the kidney: Resolution of old problems and new beginnings. Am. J. Physiol. 277(3), R607-R623 (1999).

    2. Cravatt, B.F., and Maxey, K.M. . (2004).

    3. Saghatelian, A., McKinney, M.K., Bandell, M., et al. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry 45(30), 9007-9015 (2006).