An affinity probe for PI kinases, phosphatases and PIP-binding proteins
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PtdIns-(3,4,5)-P3-biotin (sodium salt)

Item No. 10009531

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-((1-octanoyl-N'-biotinoyl-1,6-diaminohexane-2R-octanoyl)phosphatidyl)inositol-3,4,5-triphosphate,tetrasodium salt
CAS Number
1415684-80-8
Synonyms
  • DOPI-3,4,5-P3-biotin
  • Phosphatidylinositol-3,4,5-triphosphate C-8-biotin
  • PI(3,4,5)P3-biotin
  • PIP3-biotin
  • PIP3[3',4',5']-biotin
Molecular Formula
C35H61N3O24P4S • 4Na
Formula Weight
1155.8
Purity
≥98%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
H2O: 1 mg/ml
SMILES
O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@@H](O)[C@H]1OP([O-])(OC[C@@H](COC(CCCCCCCNC(CCCC[C@@H]2SC[C@@](N3[H])([H])[C@]2([H])N([H])C3=O)=O)=O)OC(CCCCCCC)=O)=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C35H65N3O24P4S.4Na/c1-2-3-4-6-10-17-27(41)58-22(19-56-26(40)16-9-7-5-8-13-18-36-25(39)15-12-11-14-24-28-23(21-67-24)37-35(44)38-28)20-57-66(54,55)62-31-29(42)32(59-63(45,46)47)34(61-65(51,52)53)33(30(31)43)60-64(48,49)50;;;;/h22-24,28-34,42-
InChi Key
IIJJVXPPNNJTJF-HXACWPDNSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 µg

    $174

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    25 µg

    $413

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    50 µg

    $696

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    100 µg

    $1,043

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    Product Description

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.1,2,3 PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Majerus, P.W. Inositol phosphate biochemistry. Annu. Rev. Biochem. 61, 225-250 (1992).

    2. Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu. Rev. Pharmacol. Toxicol. 36, 481-509 (1996).

    3. Rückle, T., Schwarz, M.K., and Rommel, C. PI3Kγ inhibition: Towards an 'aspirin of the 21st century'? Nat. Rev. Drug Discov. 5(11), 903-918 (2006).