A potent inhibitor of NF-κB
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CAY10512

Item No. 10009536

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-fluoro-2-[2-(4-methoxyphenyl)ethenyl]-benzene
CAS Number
139141-12-1
Molecular Formula
C15H13FO
Formula Weight
228.3
Purity
≥97%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: 2 mg/mlEthanol: 0.5 mg/ml
λmax
229, 318 nm
SMILES
COc1ccc(cc1)\C=C/c1ccccc1F
InChi Code
InChI=1S/C15H13FO/c1-17-14-10-7-12(8-11-14)6-9-13-4-2-3-5-15(13)16/h2-11H,1H3/b9-6+
InChi Key
ILVFNAZMSMNXJG-RMKNXTFCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $54

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    50 mg

    $216

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    100 mg

    $405

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    500 mg

    $1,753

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    Product Description

    CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heynekamp, J.J., Weber, W.M., Hunsaker, L.A., et al. Subsitituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. J. Med. Chem. 49(24), 7182-7189 (2006).

    Product Citations

    Ligresti, G., Aplin, A.C., Dunn, B.E., et al. The acute phase reactant orosomucoid-1 Is a bimodal regulator of angiogenesis with time- and context-dependent inhibitory and stimulatory properties. PLoS One 7(8), e41387 (2012).

    Chantong, B., Kratschmar, D.V., Nashev, L.G., et al. Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells. J. Neuroinflammation 9, 260 (2012).

    Ma, Q., Guin, S., Padhye, S.S., et al. Ribosomal protein S6 kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein. Mol. Cancer 10, 66 (2011).

    Li, R., Ning, Z., Maumdar, R., et al. Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: Implication of chemical components and NF-kappaB signaling. Part. Fibre Toxicol. 7, 6 (2010).