A vitamin D3 analog
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Calcipotriol (hydrate)

Item No. 10009599

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
24-cyclopropyl-(1α,3β,5Z,7E,22E,24S)-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol, monohydrate
CAS Number
147657-22-5
Synonyms
  • Calcipotriene
Molecular Formula
C27H40O3 • H2O
Formula Weight
430.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlEthanol:PBS (pH 7.2)(1:5): 0.15 mg/ml
λmax
264 nm
SMILES
C=C1[C@@H](O)C[C@H](O)C/C1=C/C=C2CCC[C@@]3(C)[C@@]\2([H])CC[C@]3([H])[C@H](C)/C=C/[C@@H](O)C4CC4.O
InChi Code
InChI=1S/C27H40O3.H2O/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2;/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3;1H2/b13-6+,19-7+,21-10-;/t17-,22-,23-,24+,25-,26+,27-;/m1./s1
InChi Key
XBKHACNRWFKJNC-MANNPBRJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $79

    Add

    25 mg

    $178

    Add

    50 mg

    $277

    Add

    100 mg

    $514

    Add
    Product Description

    Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3).1 Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response.2 Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kragballe, K. Vitamin D analogues in the treatment of psoriasis. J. Cell. Biochem. 49, 46-52 (1992).

    2. Johansen, C., Kragballe, K., Rasmussen, M., et al. Activator protein 1 DNA binding activity is decreased in lesional psoriatic skin compared with nonlesional psoriatic skin. Br. J. Dermatol. 151, 600-607 (2004).

    3. Li, M., Hener, P., Zhang, Z., et al. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc. Natl. Acad. Sci. USA 103(31), 11736-11741 (2006).

    Product Citations

    Uluckan, Ö., Bruno, S., Wang, Y., et al. Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice. Eur. J. Pharmacol. 945:175533, (2023).

    Sivasami, P., Elkins, C., Diaz-Saldana, P.P., et al. Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation. Immunity 56(8), 1844-1861 (2023).