A biologically active triterpene
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Maslinic Acid

Item No. 10009645

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2α,3β-dihydroxy-olean-12-en-28-oic acid
CAS Number
4373-41-5
Synonyms
  • Crategolic Acid
  • 2α-Hydroxyoleanoic Acid
Molecular Formula
C30H48O4
Formula Weight
472.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 20 mg/mlDMSO: PBS (pH 7.2)(1:2): 0.3 mg/mlEthanol: 0.5 mg/ml
SMILES
CC1(C)CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CCC5C(C)(C)[C@@H](O)[C@H](O)C[C@]5(C)[C@@]4([H])CC=C3[C@@]2([H])C1
InChi Code
InChI=1S/C30H48O4/c1-25(2)12-14-30(24(33)34)15-13-28(6)18(19(30)16-25)8-9-22-27(5)17-20(31)23(32)26(3,4)21(27)10-11-29(22,28)7/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)/t19-,20-,21?,22-,23+,27+,28-,29-,30?/m1/s1
InChi Key
MDZKJHQSJHYOHJ-UKSPDLIDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $35

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    5 mg

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    10 mg

    $209

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    25 mg

    $481

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    Product Description

    Maslinic acid is found in a number of natural sources, most notably pomace olive oil (orujo). This pentacyclic triterpene has an antiproliferative effect against Caco-2 cancer cells (EC50 = 15 µM), HT-29 human colon cancer cells (EC50 = 74 µM), 1321N1 astrocytoma cells (IC50 = 25 µM), and human leukemia (CCRF-CEM and CEM/ADR5000) cells (IC50 = 7 µM and 9 µM respectively).1,2,3,4 Maslinic acid's antiproliferative activity likely comes from the induction of an oxidative apoptotic pathway, causing cell cycle and cytoskeleton alterations. Maslinic acid has been found to attenuate intracellular oxidative stress via inhibition of NO and H2O2 production and reduction of pro-inflammatory cytokine generation in murine macrophages.5 Recently maslinic acid has been found to inhibit the spread of the HIV virus by inhibiting the replication of a primary HIV-1 isolate as well as decreased the cytopathic effect and p24 antigen levels in MT2 cells.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. He, X., and Liu, R.H. Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple’s anticancer activity. J. Agric. Food Chem. 55(11), 4366-4370 (2007).

    2. Martín, A.M., De La Puerta Vázquez, R., Fernández-Arche, A., et al. Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages. Free Radic. Res. 40(3), 295-302 (2006).

    3. García, A. Compound from olive-pomace oil inhibits HIV spread. 070709111536, 1-1 (2007).