PTEN (human recombinant)

Phosphatase and tensin homology on chromosome 10 (PTEN) functions as a key regulatory enzyme in many signal transduction pathways by dephosphorylating proteins and lipids such as AKT and phosphatidylinositol 3,4,5-trisphosphate (PIP₃). PTEN interacts with many other proteins to regulate cell division and migration, as well as promoting apoptosis when necessary.¹ Mutation of PTEN results in many human cancers including melanoma and prostate carcinoma, making PTEN an important tumor suppressor.^2,3 PTEN is expressed in almost all tissues of the body as a 403 amino acid protein with an estimated molecular weight of 47 kDa, however the actual migration observed on western blot may vary among distinct samples.⁴

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1. Di Cristofano, A., and Pandolfi, P.P. The multiple roles of PTEN in tumor suppression. Cell 100(4), 387-390 (2000).

2. Vivanco, I., and Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat. Rev. Cancer 2(7), 489-501 (2002).

3. Dahia, P.L.M. PTEN, a unique tumor suppressor gene. Endocr. Relat. Cancer 7(2), 115-129 (2000).

4. Steck, P.A., Pershouse, M.A., Jasser, S.A., et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 15(4), 356-362 (1997).