For immunochemical detection of the NMDA Receptor
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NMDA Receptor NR2B Subunit (Phospho-Tyr1336) Polyclonal Antibody

Item No. 10009760

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Immunogen
phosphopeptide corresponding to amino acid residues surrounding the Phospho-Tyr1336 of human NMDA Receptor NR2B Subunit
Formulation (Request formulation change)
Peptide affinity-purified antibody
Host
Rabbit
Applications
WB
Species Reactivity
(+) Human NMDA receptor(+) Rat NMDA receptor(+) Bovine NMDA receptor (expected)(+) Canine NMDA receptor (expected)(+) Chicken NMDA receptor (expected)(+) Mouse NMDA receptor (expected)(+) Non-human primates NMDA receptor (expected)(+) Zebrafish NMDA receptor (expected)
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 ea

    $464

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    Product Description

    The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development, and it has also been implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy, and ischemic neuronal death. 1,2,3 The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. 4 Phosphorylation of Tyr1336 in NR2B is thought to potentiate NMDA receptor-dependent influx of calcium.5 Ischemia may also increase the phosphorylation of this site.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grosshans, D.R., Clayton, D.A., Coultrap, S.J., et al. LTP leads to rapid surface expression of NMDA but not AMA receptors in adult rat CA1. Nat. Neurosci. 5, 27-33 (2002).

    2. Wenthold, R.J., Prybylowski, K., Standley, S., et al. Trafficking of NMDA receptors. Annu. Rev. Pharmacol. Toxicol. 43, 335-358 (2003).

    3. Carroll, R.C., and Zukin, R.S. NMDA-receptor trafficking and targeting: Implications for synaptic transmission and plasticity. Trends Neurosci. 25(11), 571-577 (2002).

    4. Ishii, T., Moriyoshi, K., Sugihara, H., et al. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. The Journal of Biological Chemisty 268(4), 2836-2843 (1993).

    5. Takasu, M.A., Dalva, M.B., Zigmond, R.E., et al. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB Receptors. Science 295, 491-495 (2002).