For immunochemical detection of Dynamin

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Product Categories

Product Type

Antibodies

Primary Antibodies

Polyclonal Antibodies

Research Area

Neuroscience

Application

Western Blot

Dynamin (Phospho-Ser⁷⁷⁴) Polyclonal Antibody

Name: Dynamin (Phospho-Ser774) Polyclonal Antibody
Brand: -

Item No. 10009785

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Immunogen

phosphopeptide corresponding to amino acid residues surrounding phospho-Ser⁷⁷⁴ of rat dynamin

Formulation (Request formulation change)

Affinity-purified IgG

Host

sheep

Applications

Species Reactivity

(+) Rat dynamin phospho-Ser774

Origin

Animal/Sheep

Shipping & Storage Information

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

1 ea

$464

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Product Description

Dynamin is a member of a group of nerve terminal proteins called dephosphins that regulate synaptic vesicle endocytosis.^1,2,3 Cyclin dependent protein kinase 5 phosphorylates dynamin at Ser⁷⁷⁴ and Ser⁷⁷⁸.⁴ Phosphorylation of these sites on dynamin is thought to play a key role in synaptic vesicle trafficking.

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Cousin, M.A., Tan, T.C., and Robinson, P.J. Protein phosphorylation is required for endocytosis in nerve terminals: potential role for the dephosphins dynamin I and synaptojanin, but not AP180 or amphiphysin. J. Neurochem. 76, 105-116 (2001).

2. Graham, M.E., O'Callaghan, D.W., McMahon, H.T., et al. Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size. Proc. Natl. Acad. Sci. USA 99(10), 7124-7129 (2002).

3. Tsuboi, T., Terakawa, S., Scalettar, B.A., et al. Sweeping model of dynamin activity. The Journal of Biological Chemisty 277(18), 15957-15961 (2002).

4. Tan, T.C., Valova, V.A., Malladi, C.S., et al. Cdk5 is essential for synaptic vesicle endocytosis. Nat. Cell Biol. 5(8), 701-710 (2003).

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