Scavenger Receptor B2/CD36 Monoclonal FITC Antibody (Clone JC63.1)

CD36, also known as scavenger receptor B2 or fatty acid translocase, is a transmembrane glycoprotein that has roles in fatty acid uptake and lipid metabolism and signaling.¹ It is composed of N- and C-terminal cytoplasmic tails, two transmembrane domains, and an extracellular loop that binds to a variety of lipid ligands, including long-chain fatty acids, oxidized LDL, and oxidized phospholipids, and protein ligands, such as thrombospondin (TSP-1), and is subject to post-translational modifications.^1,2,3 CD36 is expressed by a variety of cells, including hematopoietic cells such as platelets, monocytes, and macrophages, as well as adipocytes, enterocytes, cardiac and skeletal myocytes, and endothelial and epithelial cells.^1,4 It also exists as a soluble form, sCD36, which is produced via plasma proteases.² CD36 expression is regulated by several transcription factors, including peroxisome proliferator-activated receptor (PPAR), STAT3, and hypoxia-inducible factor-1α (HIF-1α), in a tissue-dependent manner.^3,1 It is localized to the plasma membrane and within endosomes, the endoplasmic reticulum, and mitochondria, and is translocated between these compartments in response to various stimuli, including insulin-induced PI3K signaling and muscle contraction-induced AMPK signaling, to regulate fatty acid uptake.^2,3 It has additional roles in the phagocytosis of apoptotic cells and P. falciparum-infected red blood cells (RBCs), angiogenesis, thrombosis, inflammation, and atherosclerosis, as well as cancer metastasis.^5,3 Cayman’s Scavenger Receptor B2/CD36 Monoclonal FITC Antibody (Clone JC63.1) can be used for flow cytometry (FC) and immunofluorescence (IF) applications.

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1. Glatz, J.F.C., and Luiken, J.J.F.P. Dynamic role of the transmembrane glycoprotein CD36 (SR-B₂) in cellular fatty acid uptake and utilization. J. Lipid Res. 59(7), 1084-1093 (2018).

2. Wang, J., and Li, Y. CD36 tango in cancer: Signaling pathways and functions. Theranostics 9(17), 4893-4908 (2019).

3. Yang, X., Okamura, D., Lu, X., et al. CD36 in chronic kidney disease: Novel insights and therapeutic opportunities. Nat. Rev. Nephrol. 13(12), 769-781 (2017).

4. Glatz, J.F.C., and Luiken, J.J.F.P. From fat to FAT (CD36/SR-B₂): Understanding the regulation of cellular fatty acid uptake. Biochimie 136, 21-26 (2017).

5. Maréchal, L., Laviolette, M., Rodrigue-Way, A., et al. The CD36-PPARγ pathway in metabolic disorders. Int. J. Mol. Sci. 19(5), 1529 (2017).

Petersen, L.K., York, A.W., Lewis, D.R., et al. Amphiphilic nanoparticles repress macrophage atherogenesis: novel core/shell designs for scavenger receptor targeting and down-regulation. Mol. Pharm. 11(8), 2815-2824 (2014).

Gowda, N.M., Wu, X., Kumar, S., et al. CD36 contributes to malaria parasite-induced pro-inflammatory cytokine production and NK and T cell activation by dendritic cells. PLoS One 8(10), e77604 (2013).