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GW 590735

Item № 10009880
CAS № 622402-22-6
Purity ≥98%
product image
                (CAS 622402-22-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $43.00 0.00
     5 mg $194.00 0.00
     10 mg $344.00 0.00
     25 mg $753.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

The peroxisome proliferator-activated receptors (PPARs) α, γ, and δ are ligand-activated transcription factors that play a key role in lipid homeostasis. Activation of PPARα results in increased clearance of triglyceride (TG) rich very low-density lipoprotein (VLDL) via a reduction in plasma levels of ApoCIII and in upregulation of ApoA1, the principal lipoprotein component of HDL.1 GW 590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ.1

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Technical Information
Formal Name
2-methyl-2-(4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)methyl)phenoxy)propanoic acid
CAS Number
622402-22-6
Molecular Formula
C23H21F3N2O4S
Formula Weight
478.5
Purity
≥98%
Formulation
A crystalline solid
λmax
224, 311 nm
SMILES
O=C(NCc1ccc(cc1)OC(C)(C)C(=O)O)c1sc(nc1C)c1ccc(cc1)C(F)(F)F
InChI Code
InChI=1S/C23H21F3N2O4S/c1-13-18(33-20(28-13)15-6-8-16(9-7-15)23(24,25)26)19(29)27-12-14-4-10-17(11-5-14)32-22(2,3)21(30)31/h4-11H,12H2,1-3H3,(H,27,29)(H,30,31)
InChI Key
ILUPZUOBHCUBKB-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Sierra, M.L., Beneton, V., Boullay, A.B., et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents Journal of Medicinal Chemistry 50, 685-695 (2007).

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