A potent and selective agonist of PPARα
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GW 590735

Item No. 10009880

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-2-[4-[[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]carbonyl]amino]methyl]phenoxy]-propanoic acid
CAS Number
343321-96-0
Molecular Formula
C23H21F3N2O4S
Formula Weight
478.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 0.25 mg/ml
λmax
224, 311 nm
SMILES
O=C(NCc1ccc(cc1)OC(C)(C)C(=O)O)c1sc(nc1C)c1ccc(cc1)C(F)(F)F
InChi Code
InChI=1S/C23H21F3N2O4S/c1-13-18(33-20(28-13)15-6-8-16(9-7-15)23(24,25)26)19(29)27-12-14-4-10-17(11-5-14)32-22(2,3)21(30)31/h4-11H,12H2,1-3H3,(H,27,29)(H,30,31)
InChi Key
ILUPZUOBHCUBKB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $61

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    5 mg

    $260

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    10 mg

    $462

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    25 mg

    $1,006

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    Product Description

    GW 590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sierra, M.L., Beneton, V., Boullay, A.B., et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents. J. Med. Chem. 50(4), 685-695 (2007).