A COX-2 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Inotilone

Item No. 10010089

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2Z)-2-[(3,4-dihydroxyphenyl)methylene]-5-methyl-3(2H)-furanone
CAS Number
906366-79-8
Molecular Formula
C12H10O4
Formula Weight
218.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 1 mg/ml
λmax
246, 265, 386 nm
SMILES
OC1=CC=C(/C=C2OC(C)=CC\2=O)C=C1O
InChi Code
InChI=1S/C12H10O4/c1-7-4-11(15)12(16-7)6-8-2-3-9(13)10(14)5-8/h2-6,13-14H,1H3/b12-6-
InChi Key
NLZQGBCUKNUDED-SDQBBNPISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $49

    Add

    5 mg

    $178

    Add

    10 mg

    $329

    Add

    25 mg

    $702

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Inotilone is a cyclooxygenase (COX) inhibitor found in mushrooms of Phellinus and Inonotus sps. that inhibits COX-2 over COX-1 with IC50 values of 0.03 and 0.36 µM, respectively.1,2 It is a poor inhibitor of hydroxysteroid dehydrogenase and xanthine oxidase (IC50s = 50.4 and 9.1 µM, respectively).1,2 Inotilone demonstrates anti-inflammatory, antiviral, and antioxidant effects in various experimental models.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wangun, H.V.K., Härtl, A., Kiet, T.T., et al. Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors. Org. Biomol. Chem. 4, 2545-2548 (2006).

    2. Shamshina, J.L., and Snowden, T.S. Convergent synthesis of potent COX-2 inhibitor inotilone. Tetrahedron Lett. 48, 3767-3769 (2007).

    3. Huang, G.-J., Huang, S.-S., and Deng, J.-S. Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-kB, and MAPK activation in vitro and in vivo. PLoS One 7(5), e35922 (2012).

    4. Hwang, B.S., Lee, M.-S., Lee, S.W., et al. Neuraminidase inhibitors from the fermentation broth of Phellinus linteus. Mycobiology 42(2), 189-192 (2014).

    5. Lee, M.-S., Hwang, B.S., Lee, I.-K., et al. Chemical constituents of the culture broth of Phellinus linteus and their antioxidant activity. Mycobiology 43(1), 43-48 (2015).