A lysophosphatidic acid analog
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1-Palmitoyl-2-hydroxy-sn-glycero-3-PA

Item No. 10010094

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
hexadecanoic acid, 2R-hydroxy-3-(phosphonooxy)propyl ester
CAS Number
7220-34-0
Synonyms
  • 1-Hexadecanoyl-2-hydroxy-sn-glycero-3-phosphate
  • 16:0 LPA
  • LPA 16:0
  • PA(16:0/0:0)
  • 1-Palmitoyl LPA
  • 1-Palmitoyl Lysophosphatidic Acid
Molecular Formula
C19H39O7P
Formula Weight
410.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10mg/mlEthanol:PBS (pH 7.2) (1:9): Slightly soluble: 0.1-1mg/ml
SMILES
CCCCCCCCCCCCCCCC(OC[C@@H](O)COP(O)(O)=O)=O
InChi Code
InChI=1S/C19H39O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(21)25-16-18(20)17-26-27(22,23)24/h18,20H,2-17H2,1H3,(H2,22,23,24)/t18-/m1/s1
InChi Key
YNDYKPRNFWPPFU-GOSISDBHSA-N
Side Chain Carbon Sum
16:0
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    1-Palmitoyl-2-hydroxy-sn-glycero-3-PA (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of at least five different G protein-coupled receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.1,2 Additionally, 1-palmitoyl LPA enhances the action of β-lactam antibiotics (ampicillin, piperacillin, and ceftazidime) on various strains of P. aeruginosa, a pathogen associated with pulmonary disease and pneumonia, via binding both Ca2+ and Mg2+.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Noguchi, K., Ishii, S., and Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. The Journal of Biological Chemisty 278(28), 25600-25606 (2003).

    2. Moolenaar, W.H. LPA: A novel lipid mediator with diverse biological actions. Trends Cell Biol. 4(6), 213-219 (1994).

    3. Krogfelt, K.A., Utley, M., Krivan, H.C., et al. Specific phospholipids enhance the activity of β-lactam antibiotics against Pseudomonas aeruginosa. J. Antimicrob. Chemother. 46(3), 377-384 (2000).