Fluorescent CNGA2 channel activator
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8-DY547-cGMP

Item No. 10010109

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-ethyl-2-((4E)-4-(1-ethyl-3-(4-(2-(methylthio)ethylamino)-4-oxobutyl)-5-sulfonatoindolin-2-ylidene)but-2-en-2-yl)-3,3-dimethyl-3H-indolium-5-sulfonate-guanosine-3',5'-cyclic monophosphate, disodium salt
Molecular Formula
C42H55N8O14PS3 • 2Na
Formula Weight
1069.1
Purity
≥98%
Formulation (Request formulation change)
A 1 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
SMILES
CC[N+](C(C=C(S(=O)([O-])=O)C=C1)=C1C2(C)C)=C2/C=C/C=C3C(CCCC(NCCSC4NC(C(NC(N)=N5)=O)C5N4C6OC(COP(O7)([O-])=O)C7C6O)=O)(C)C(C=C(S(=O)([O-])=O)C=C8)C8N/3CC.[Na+].[Na+]
InChi Code
InChI=1S/C42H57N8O14PS3.2Na/c1-6-48-27-16-14-23(67(56,57)58)20-26(27)42(5,31(48)11-8-10-30-41(3,4)25-15-13-24(68(59,60)61)21-28(25)49(30)7-2)17-9-12-32(51)44-18-19-66-40-45-33-36(46-39(43)47-37(33)53)50(40)38-34(52)35-29(63-38)22-62-65(54,55)64-35;;/
InChi Key
VKTWASDKFOZMCE-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 µg

    $165

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    100 µg

    $312

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    Product Description

    8-DY547-cGMP is a fluorescently-labeled cyclic nucleotide that can be used to study CNGA2 channel activation. 8-DY547-cGMP and cGMP open the channel with equal efficiency and control of the channel activity is rapid and reversible. The difference in fluorescence (ΔF) can be determined by using DY647.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Biskup, C., Kusch, J., Schulz, E., et al. Relating ligand binding to activation gating in CNGA2 channels. Nature 446, 440-443 (2007).